反应详情

A mixture of 1-(2-nitro-4-trifluoromethylphenyl)-butan-1,3-dione (11.0 g), triethyl orthoformate (11.3 g) and acetic anhydride (12.3 g) was stirred and heated at reflux for 3 hours. After cooling, the mixture was evaporated to dryness. Toluene (50 ml) was added and the mixture was evaporated to dryness to give 2-ethoxymethylene-1-(2-nitro-4-trifluoromethylphenyl)-butan-1,3-dione as a crude brown oil which was not further purified.

1. temperatureheated
2. temperatureat reflux for 3 hours
3. temperatureAfter cooling
4. customthe mixture was evaporated to dryness
5. additionToluene (50 ml) was added
6. customthe mixture was evaporated to dryness