HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → (1H-Imidazol-1-yl)(1-methylcyclopropyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 1-Methylcyclopropane-1-carbonyl chloride | HCID 12789939 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1H-Imidazol-1-yl)(1-methylcyclopropyl)methanone | HCID 45084280 | 91% |
Reaction Steps
A solution of 1-methylcyclopropylcarbonyl chloride (11.8 g) in toluene (15 ml) was added dropwise to a solution of imidazole (13.6 g) in tetrahydrofuran (100 ml) whilst maintaining the temperature below 25° C. The mixture was stirred for 3 hours and filtered. The filtrate was evaporated to dryness to give 1-(1-methylcyclopropylcarbonyl)-imidazole (13.6 g) as a white solid, mp 34°-35° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05650533 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-c0917e93d476446a8a6fd34baee2a500 |
| Source note | uspto-grants-1997_07 |