p-Toluenesulfonic acid → HCID 53671963, compound

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A mixture of crude t-butyl 2-[2-bromo-3-(2-methoxyethoxy)-4-methylsulphonylbenzoyl]-3-cyclopropyl-3-oxopropanoate (10.2 g) and 4-toluenesulphonic acid (2 g) in dry toluene was stirred and heated at reflux for 2 hours. The cooled mixture was washed with water, dried (anhydrous magnesium sulphate) and filtered. The filtrate was evaporated to dryness to give 3-cyclopropyl-1-[2-bromo-3-(2-methoxyethoxy)-4-methylsulphonylphenyl]propan-1,3-dione (7.5 g) as a brown oil which was not purified further NMR(CDCl3) 0.9(4H, m), 1.5(1H, m), 3.1(3H, s), 3.3(3H,s), 3.6(2H, t), 4.2(2H, t), 5.7(1H, s), 7.15(1H, d), 7.8(1H, d).

Provenance & Evidence