Sodium Hydroxide → HCID 19030235, compound

Participants

Reaction Conditions

Reaction Steps

Next, to a mixture in which 530 g of ice and 125 g of water were added to 126 g of sodium hydroxide was gradually added dropwise 125 g of bromine. After completion of dropwise addition, a solution of the previously obtained 45 g of 3,4-difluoro-4'-acetylbiphenyl dissolved in 230 ml of dioxane was added dropwise to the mixture at a temperature of 20° C. or lower. After completion of the dropwise addition, the mixture was heated to 50° C. and reacted for 1 hour. After the reaction, 100 ml of a 40% aqueous sodium bisulfite solution was added to precipitate crystals. The crystals were collected by filtration, washed well with methanol and purified by recrystallization to obtain 36 g of 3,4-difluorobiphenyl carboxylic acid.

Provenance & Evidence