Sulfuric Acid → HCID 40479468, compound

Participants

Reaction Conditions

Reaction Steps

Next, to a solution comprising 4 g of lithium aluminum hydride dissolved in 200 ml of tetrahydrofuran was added dropwise a solution comprising 30 g of the previously obtained methyl 3,4-difluorobiphenyl carboxylate and 100 ml of tetrahydrofuran with stirring at -10° C., and the mixture was stirred for one hour at the same temperature to proceed the reaction. After completion of the reaction, to the reaction mixture was added 30 g of sulfuric acid and the resulting mixture was extracted with toluene. The reaction mixture was washed with a saturated NaCl aqua, dried, and the solvent was removed under reduced pressure. The residue was purified by distillation under reduced pressure (165° C/1 mmHg) to obtain 28 g of 4-(3,4-difluorophenyl)benzyl alcohol.

Provenance & Evidence