HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → 4-methyl-4(RS)-tetrahydropyran-2-yloxy-1,5-octadiyne
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 4-methyl-1,5-octadiyn-4(RS)-ol | HCID 21322039 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-methyl-4(RS)-tetrahydropyran-2-yloxy-1,5-octadiyne | HCID 21322047 | — |
Reaction Steps
4-Methyl-1,5-octadiyn-4(RS)-ol is reacted with dihydropyran in the presence of p-toluenesulfonic acid in dry benzene to provide 4-methyl-4(RS)-tetrahydropyran-2-yloxy-1,5-octadiyne which in turn is reacted with triethyl tin hydride to provide 4-methyl-4(RS)-tetrahydropyran-2-yloxy-oct-5-yn-trans-1-enyl triethyl tin, having the following structural formula: ##STR12##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151187 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-f7c5e08e299e4030a0457aa063a10d76 |
| Source note | uspto-grants-1979_04 |