Acetaldehyde → HCID 19030393, compound

HRID 266661Notes

Reaction equation

HRID 266661 reaction equation
[CH:1](=O)[CH3:2].[CH:4]1([NH2:11])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[OH-].[K+]>>[CH:1](=[N:11][CH:4]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 3

HCID 177AcetaldehydeHCID 2899CycloheptylamineHCID 14797Potassium Hydroxide

Product 1

HCID 19030393HCID 19030393, compoundYield 86%

Procedure

90% Acetaldehyde (19.55 g) was added dropwise to cycloheptylamine (45.28 g) with ice bath cooling over about 2 hours. After the completion of the dropwise addition, potassium hydroxide, in solid form, was added and the organic layer was separated by a separatory funnel. This liquid was distilled under reduced pressure to obtain pure N-ethylidenecycloheptylamine (47.92 g). b.p. 100°-104° C./106.4 mbar.

Workup

  1. temperaturecooling over about 2 hours
  2. additionin solid form, was added
  3. customthe organic layer was separated by a separatory funnel
  4. distillationThis liquid was distilled under reduced pressure

Sources & evidence

ORD record
ord-66d9127fc0e74cae8759e00507d6c7c9
Source dataset
uspto-grants-1997_07
Patent number
US05652198

Reaction notes

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