Acetic Anhydride → HCID 54564406, compound

Participants

Reaction Steps

To a cooled solution of N-phenyl β-(4-hydroxy-5,6,7,8-tetrahydronaphth-1-yl)-α-cyanoacrylamide (3.184 g, 0.010 mol) in dry pyridine (5 ml) was added acetic anhydride (2.040 g, 0.020 mol) and the mixture maintained at 0°-5° C. overnight. Thereupon the mixture was concentrated under vacuum, the residue dissolved in dichloromethane, the organic layer washed with water and then evaporated under reduced pressure. The crude product was crystallized from chloroform/methanol to yield pure title compound in about 80% yield.

Provenance & Evidence