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Oxalyl chloride → 4-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 4-((4-Pyridyl)piperazin-1-yl)benzoic acid | HCID 18918300 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[(4-Pyridyl)piperazin-1-yl]benzoyl chloride | HCID 18918364 | — |
反応手順
Oxalyl chloride (0.5 ml) was added to a stirred suspension of 4-((4-pyridyl)piperazin-1-yl)benzoic acid in dichloromethane (15 ml), followed by DMF (1 drop). The mixture was stirred for 2 hours and evaporated to dryness to give 4-[(4-pyridyl)piperazin-1-yl]benzoyl chloride which was used immediately.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05652242 |
| 出典データセット | uspto-grants-1997_07 |
| ORD ID | ord-5fc6cac3a22a4296b8cc0cb66abd3fb2 |
| 出典メモ | uspto-grants-1997_07 |