反应详情

Bromine (2.09 ml) has added dropwise over ten minutes to a stirred solution of the product of step (i) above (9.44 g) in carbon tetrachloride (2001 ml). The solution was stirred for 16 hours, then the solvent was evaporated invacuo to give an orange oil. A solution of this oil, in a small volume of dichloromethane, was filtered through silica and the clear filtrate, on evaporation, gave methyl 4-(2-bromo-2,2-dimethylacetyl)phenoxyacetate, 11.3 g, as a white crystalline solid: m.p. 46°-50° C.; NMR (d6DMSO) δ 8.09 (2H, d), 7.05 (2H, d), 4.92 (2H, s), 3.72 (3H, s), 2.00 (6H, s).

1. customthe solvent was evaporated invacuo
2. customto give an orange oil
3. filtrationA solution of this oil, in a small volume of dichloromethane, was filtered through silica
4. customthe clear filtrate, on evaporation