HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Dimaprit hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 3-(Dimethylamino)propyl chloride hydrochloride | HCID 94308 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Dimaprit hydrochloride | HCID 90045 | — |
Reaction Steps
A mixture of 1-chloro-3-(dimethylamino)propane hydrochloride (200 g), thiourea (98.1 g) and ethanol (11) was stirred and heated under reflux for 25 hours. The solution was cooled to ambient temperature and ethyl acetate added until permanent opalescence was obtained. The mixture was stored at 4° C. overnight then filtered to give S-[3-(dimethylamino)propyl]isothiourea dihydrochloride as a colourless solid. (283 g), m.p. 155°-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05652271 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-46b82e97efc7465abd875062f6e51b31 |
| Source note | uspto-grants-1997_07 |