反应详情

A stirred mixture of 1-chloro-4-(dimethylamino)-butane hydrochloride (115 g), thiourea (51.9 g) and ethanol (500 ml) was heated under reflux for 24 hours then allowed to stand at 4° C. for 24 hours. The resulting solid was collected by filtration, washed with ether, and dried in vacuo at ambient temperature for 24 hours to give S-[4-(dimethylamino)butyl]isothiourea dihydrochloride as an off-white solid (140 g), m.p. 179°-182° C.

1. temperaturewas heated
2. temperatureunder reflux for 24 hours
3. filtrationThe resulting solid was collected by filtration
4. washwashed with ether
5. customdried in vacuo at ambient temperature for 24 hours