HCID 19030483, compound → HCID 19030524, compound

HRID 266893Notes

Reaction equation

HRID 266893 reaction equation
Cl.C([N:9]1[CH2:14][CH2:13][C:12]2([CH:19]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:18]3[CH:26]=[CH:27][CH:28]=[CH:29][C:17]=3[C:16](=[O:30])[O:15]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>C(O)C>[C:20]1([CH:19]2[C:12]3([CH2:13][CH2:14][NH:9][CH2:10][CH2:11]3)[O:15][C:16](=[O:30])[C:17]3[CH:29]=[CH:28][CH:27]=[CH:26][C:18]2=3)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 1

HCID 19030483HCID 19030483, compound

Product 1

HCID 19030524HCID 19030524, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared by the procedure described in Example 3, Step A from 1'-benzyl-1,4-dihydro-4-phenylspiro(3H-2-benzopyran-3,4'-piperidine)-1-one hydrochloride, (8 mg, 0.019 mmol) and ethanol (5 mL). Reaction time: 45 minutes. Yield 5.5 mg (98.5%). FAB-MS calc. for C19H19NO2 293; found 294 (M+H, 93%).

Workup

  1. customPrepared by the procedure
  2. customReaction time
  3. custom45 minutes

Sources & evidence

ORD record
ord-927be92e1c7b4eefa08b3b895201b567
Source dataset
uspto-grants-1997_07
Patent number
US05652235

Reaction notes

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