4-Nitroaniline → HCID 178526680, compound

Participants

Reaction Steps

Para-nitroaniline (13.8 g) was dissolved into acetone (150 ml) at room temperature. 2,4,6-Trichlorotriazine (18.4 g) was dissolved into acetone (100 ml). Then the trichlorotriazine solution was dropwisely added to the p-nitroaniline solution as the p-nitroaniline solution was cooled with iced water. After the reaction was carried out for 2 hours at 0° C., an aqueous sodium bicarbonate solution (8.4 g of sodium bicarbonate being dissolved in 100 ml of water) was dropwisely added to the solution over 30 minutes. Then, the cooling was stopped by removing the ice bath and the solution was stirred until the temperature of the solution became room temperature. The reaction product was filtered off, washed with water and vacuum dried to obtain 23 g of 2,4-dichloro-6-p-nitroanilinotriazine. The chemical structure of the reaction product was confirmed by NMR and the melting point.

Provenance & Evidence