反应详情

To a stirred chloroform solution (20 ml) containing 2.9 g of 1,4,7,10-tetraazacyclododecane (16.8 mmole) was added a chloroform solution (20 ml) containing 2.1 g of 2-methoxy-5-nitrobenzyl bromide (8.5 mmole) in one portion. After stirring at room temperature for three hours the reaction mixture was filtered and the filtrate concentrated (in vacuo) to give a residue which was chromatographed (silica, Solvent System 3). The monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.), and characterized by:

1. filtrationwas filtered
2. concentrationthe filtrate concentrated (in vacuo)
3. customto give a residue which
4. customwas chromatographed (silica, Solvent System 3)
5. customThe monoalkylated product was isolated in 79 percent yield (MP=154°-156° C.)