HCID 15297752, compound → HCID 131719050, compound

HRID 266925Notes

Reaction equation

HRID 266925 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][C:4]=1[CH:12]([N:16]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]([OH:31])=[O:30])[CH2:24][CH2:23][N:22]([CH2:32][C:33]([OH:35])=[O:34])[CH2:21][CH2:20][N:19]([CH2:36][C:37]([OH:39])=[O:38])[CH2:18][CH2:17]1)[C:13]([OH:15])=[O:14].[H][H]>O.[Pt]=O>[NH4+:9].[NH4+:9].[NH4+:9].[NH4+:9].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][C:4]=1[CH:12]([N:16]1[CH2:27][CH2:26][N:25]([CH2:28][C:29]([O-:31])=[O:30])[CH2:24][CH2:23][N:22]([CH2:32][C:33]([O-:35])=[O:34])[CH2:21][CH2:20][N:19]([CH2:36][C:37]([O-:39])=[O:38])[CH2:18][CH2:17]1)[C:13]([O-:15])=[O:14]

Participants

5

Reactant 2

HCID 15297752HCID 15297752, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 131719050HCID 131719050, compoundYield 420.2%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 962WaterSolvent

Procedure

To a solution of α-(2-methoxy-5-nitrophenyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (157 mg) (prepared by the procedure of Example 11) in water (20 ml) was added platinum oxide (20 mg). This mixture was hydrogenated (1 atmosphere hydrogen) for 1 hour at room temperature. After filtration, the material was further purified by chromatography (silica gel, Solvent System 5) to yield the title compound (141 mg) as an off-white solid, and characterized by:

Workup

  1. customfor 1 hour
  2. customat room temperature
  3. filtrationAfter filtration
  4. customthe material was further purified by chromatography (silica gel, Solvent System 5)

Sources & evidence

ORD record
ord-7e1aa3e9116247d09031db54425016e9
Source dataset
uspto-grants-1997_07
Patent number
US05652361

Reaction notes

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