反应详情

The 1-methyl-benzimidazole of Step A was dissolved in ether and 1.4 equivalents of ethyl bromoacetate were added thereto. The ether solution was allowed to stand for several days and the crystals formed were recovered for a 62% yield of 1-ethoxycarbonylmethyl-3-methyl-benzimidazolium bromide. After crystallization from an ethyl acetate-methanol mixture, the product melted at 160°-161° C.

1. waitto stand for several days
2. customthe crystals formed