HuagongsheHuagongshe Chemistry Print Report · For research reference only
N2 [3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1-phenyl-L-prolinamide → N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1-phenyl-L-prolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N2 [3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1-phenyl-L-prolinamide | HCID 86746224 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N2 [3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1-phenyl-L-prolinamide | HCID 86746222 | 94.6% |
Reaction Steps
A solution of 0.45 g of N2 -[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-phenylbutyl]-N1 -phenyl-L-prolinamide in 20 ml of ethanol was hydrogenated over 10% palladium-on-carbon for 4 hours to give 0.315 g of N2 -[3(S)-amino-2(R)-hydroxy-4-phenylbutyl]-N1 -phenyl-L-prolinamide in the form of a white solid: MS: m/e 354 [M+]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05652369 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-3b2ae3c2b1864152bead81c8e36f71aa |
| Source note | uspto-grants-1997_07 |