反应详情

5 g of 3-(2-naphthyl)-L-alanine and 0.93 g of sodium hydroxide in 12 ml of water were cooled to 0° C. and stirred while a solution of 1.4 g of sodium hydroxide in 9 ml of water and 5 ml of benzyl chloroformate were added simultaneously during 10 minutes. Stirring was continued for 2 hours and the mixture was allowed to come to room temperature. The mixture was diluted with water and then extracted with diethyl ether. The aqueous layer was acidified with 4 ml of concentrated hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extracts were back-washed with water. The combined ethyl acetate extracts were dried over sodium sulphate, filtered, evaporated and triturated with petroleum ether (boiling point 40°-60° C.) to give 7.5 g of N-(benzyloxycarbonyl)-3-(2-naphthyl)-L-alanine of melting point 109°-111° C.

1. additionwere added simultaneously during 10 minutes
2. customto come to room temperature
3. extractionextracted with diethyl ether
4. extractionextracted with ethyl acetate
5. washThe ethyl acetate extracts were back-washed with water
6. dry with materialThe combined ethyl acetate extracts were dried over sodium sulphate
7. filtrationfiltered
8. customevaporated
9. customtriturated with petroleum ether (boiling point 40°-60° C.)