Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 6-Nitro-3-phenylacetamidobenzoic acid | HCID 193864 | — |
| Reactant | Penicillin V Potassium | HCID 23676814 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 6-Aminopenicillanic acid | HCID 11082 | 86.1% |
Reaction Steps
290 g of carrier-bound penicillinacylase according to Example 4, having an enzymatic activity of 2,803 U (NIPAB test) and 138 g of potassium penicillin V are added to 2,000 ml of water and stirred for 9 hours at 38°C. The pH value is kept constant at 7.8 by continuous addition of triethylamine. The mixture is worked up as described in Example 1. Yields of 6-APA 64.3 g (86.1% of theory); purity 97.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03941756 |
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| Source dataset | uspto-grants-1976_03 |
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| ORD ID | ord-b637f9b0888d47a1a842be6a33c686f8 |
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| Source note | uspto-grants-1976_03 |
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