Epichlorohydrin → HCID 135819054, compound

HRID 267186Notes

Reaction equation

HRID 267186 reaction equation
[NH2:1][C:2]1[NH:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[OH-].[Na+].[CH2:13]([CH:15]1[O:17][CH2:16]1)Cl>O>[OH:17][CH:15]1[CH2:16][N:6]2[C:2](=[N:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=32)[NH:1][CH2:13]1

Participants

5

Reactant 3

HCID 7835EpichlorohydrinHCID 136242-AminobenzimidazoleHCID 14798Sodium Hydroxide

Product 1

HCID 135819054HCID 135819054, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.33 g. (0.01 moles) of 2-amino-benzimidazole are dissolved in 100 ml. of alcohol, and 0.4 g. (0.01 moles) of sodium hydroxide dissolved in 5 ml. of water are added to the mixture, followed by the addition of 0.92 g. (0.01 moles) of epichlorohydrine. The reaction mixture is boiled for about 3 hours. The reaction is completed when the inorganic salt ceases to separate. The separated sodium chloride is filtered off, washed with 2 × 5 ml. of alcohol, and the combined filtrate and wash is evaporated to dryness. 1.8 g. (80%) of white, crystalline 1,2,3,4-tetrahydro-3-hydroxy-pyrimido[1,2-a]benzimidazole are obtained; m.p.: 158°-160°C (heating rate: 4°C/min.).

Workup

  1. additionfollowed by the addition of 0.92 g
  2. customto separate
  3. filtrationThe separated sodium chloride is filtered off
  4. washwashed with 2 × 5 ml
  5. washof alcohol, and the combined filtrate and wash
  6. customis evaporated to dryness

Sources & evidence

ORD record
ord-c6d7c234e4e649648b1e97c8b418d6db
Source dataset
uspto-grants-1976_03
Patent number
US03941788

Reaction notes

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