4-[4-(alpha-Cyclohexyl-alpha-hydroxybenzyl)piperidino]4'-tert-butylbutyrophenone hydrochloride → alpha-(4-Tert-butylphenyl)-4-(alpha-cyclohexyl-alpha-hydroxybenzyl)-1-piperidinebutanol

Participants

Reaction Steps

When in the procedure of Example 1 an appropriate amount of 4-[4-(α-cyclohexyl-α-hydroxybenzyl)piperidino]4'-tert-butylbutyrophenone hydrochloride is substituted for 4-[4-[α-(p-tert-butylphenyl)-α-hydroxybenzyl]piperidino]butyrophenone hydrochloride and the reaction mixture is refluxed for three hours, α-(4-tert-butylphenyl)-4-(α-cyclohexyl-α-hydroxybenzyl)-1-piperidinebutanol is obtained, M.P. 75°-81°C. This compound was converted to the the hydrochloride salt, M.P. 240°-242.5°C. (dec.) by the usual methods.

Provenance & Evidence