Acetyl chloride → HCID 178440028, compound

HRID 267203Notes

Reaction equation

HRID 267203 reaction equation
[CH2:1]([NH:3][C:4]1[NH:9][CH2:8][C:7]2=[C:10]([CH3:16])[N:11]=[C:12]([CH2:13][CH2:14][CH3:15])[N:6]2[N:5]=1)[CH3:2].[C:17]([Cl:20])(=[O:19])[CH3:18]>C(O)(=O)C>[ClH:20].[CH2:1]([N:3]([C:4]1[NH:9][CH2:8][C:7]2=[C:10]([CH3:16])[N:11]=[C:12]([CH2:13][CH2:14][CH3:15])[N:6]2[N:5]=1)[C:17](=[O:19])[CH3:18])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178440029HCID 178440029, compound

Product 1

HCID 178440028HCID 178440028, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Ethylamino-3,4-dihydro-5-methyl-7-propylimidazo[5,1-f]-as-triazine (Example 12e) (1.1 g.) and acetyl chloride (1.65 ml.) in glacial acetic acid (10 ml.) were heated on a steam bath for 16 hours. The acetic acid was distilled off and the residue was crystallised from a mixture of isopropanol and ether to give a solid, m.p. 190°-192° (73%).

Workup

  1. distillationThe acetic acid was distilled off
  2. customthe residue was crystallised from a mixture of isopropanol and ether
  3. customto give a solid, m.p. 190°-192° (73%)

Sources & evidence

ORD record
ord-e83277f984564296abcadf2c3c088bea
Source dataset
uspto-grants-1976_03
Patent number
US03941785

Reaction notes

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