Acetyl chloride → HCID 178440030, compound

HRID 267204Notes

Reaction equation

HRID 267204 reaction equation
[NH2:1][C:2]1[NH:7][CH2:6][C:5]2=[C:8]([CH3:14])[N:9]=[C:10]([CH2:11][CH2:12][CH3:13])[N:4]2[N:3]=1.[C:15]([Cl:18])(=[O:17])[CH3:16]>C(O)(=O)C>[ClH:18].[CH3:14][C:8]1[N:9]=[C:10]([CH2:11][CH2:12][CH3:13])[N:4]2[C:5]=1[CH2:6][NH:7][C:2]([NH:1][C:15](=[O:17])[CH3:16])=[N:3]2

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 178440032HCID 178440032, compound

Product 1

HCID 178440030HCID 178440030, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2-Amino-3,4-dihydro-5-methyl-7-propylimidazo[ 5,1-f]-as-triazine (Example 1a) (1.9 g.) and acetyl chloride (1.8 g.) in acetic acid (20 ml., glacial) were heated at 100° for 3 hours. The solution was evaporated under reduced pressure and the residue was crystallised from a mixture of ethanol and ethyl acetate to give a white solid m.p. 302°.

Workup

  1. customThe solution was evaporated under reduced pressure
  2. customthe residue was crystallised from a mixture of ethanol and ethyl acetate

Sources & evidence

ORD record
ord-f7e86becbdca41aa8163ddd3389381c1
Source dataset
uspto-grants-1976_03
Patent number
US03941785

Reaction notes

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