Ammonium Chloride → HCID 178432735, compound

Participants

Reaction Steps

2-Amino-3,4-dihydro-7-isobutyl-5-methylimidazo [5,1-f]-as-triazine (Example 3f) (2 g.) in dry ether (50 ml) was added to methyl magnesium iodide (prepared from magnesium (1.17 g.) and methyl iodide (2.56 ml.)) in ether (50 ml.). The mixture was heated under reflux for 2 hours and kept overnight. Aqueous ammonium chloride (100 ml., 1%) was added and the ether layer was separated. The aqueous layer was kept for 4 days and the solid that crystallised was collected and crystallised from a mixture of ethanol and ethyl acetate and had m.p. 265°-267°. (The hydrochloride had m.p. 142°-143°).

Provenance & Evidence