Bromobenzene → HCID 21555791, compound

Participants

Reaction Steps

From 31.4 grams (0.2 mole) bromobenzene and 4.86 grams (0.2 mole) magnesium turnings in 150 ml ether there was prepared a solution of phenylmagnesium bromide which was added dropwise at -5°C to a solution of 18.7 grams (0.1 mole) 5-benzoyl-3-methylisoxazole. Heating was effected slowly, followed by boiling under reflux for one hour and poured onto ice. After acidification with 25 ml hydrochloric acid, the ethereal phase was separated; washing with bicarbonate solution was effected, followed by drying and concentration. The residue was crystallized with ether/petroleum ether. 21 grams bis-phenyl-(3-methylisoxazol-5-yl)-carbinol of the melting point 116°-118°C. were obtained.

Provenance & Evidence