Ammonia → HCID 21555760, compound

Participants

Reaction Steps

About 15.5 g. of 3,5-dimethoxyphenyl 6-benzyl-2-pyridyl ketone hydrochloride in 55 ml. of constant boiling hydrobromic acid were heated under reflux for 12 hours. Removal of the solvent gave a tacky residue which was basified with ammonia solution and was extracted three times with a total of 90 ml. of boiling ethyl acetate. The extracts were washed twice with a total of 50 ml. of water, dried over magnesium sulfate and treated with charcoal. Removal of the solids and treatment of the filtrate with hydrogen chloride yielded 3.52 g. of a khaki-colored salt. Nuclear magnetic spectroscopy revealed that the methoxy groups had been removed and the product was used without further purification for the next step.

Provenance & Evidence