6-Methylpyridine-2-carboxylic acid → HCID 21555749, compound

HRID 267231Notes

Reaction equation

HRID 267231 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([O:11]C)[CH:10]=1)[CH:6]=[O:7].C[C:14]1[N:19]=[C:18]([C:20](O)=O)[CH:17]=[CH:16][CH:15]=1>>[CH3:20][C:18]1[N:19]=[C:14]([C:6]([C:5]2[CH:8]=[C:9]([OH:11])[CH:10]=[C:3]([OH:2])[CH:4]=2)=[O:7])[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 702826-Methylpyridine-2-carboxylic acidHCID 817473,5-Dimethoxybenzaldehyde

Product 1

HCID 21555749HCID 21555749, compound

Procedure

3,5-Dihydroxyphenyl 6-methyl-2-pyridyl ketone is prepared according to example 1 from 3,5-dimethoxybenzaldehyde and 6-methyl picolinic acid. This intermediate is then reacted according to example 2 and purified to yield pure erythro-α-(3,5-dihydroxyphenyl)-α-(6-phenethyl-2-piperidinyl)methanol hydrochloride, m.p. 285°C.

Workup

  1. customThis intermediate is then reacted
  2. custompurified

Sources & evidence

ORD record
ord-849991630d7448508221f3560bf3d58f
Source dataset
uspto-grants-1976_03
Patent number
US03941796

Reaction notes

Loading…