Ethylenediamine → 1,2-bis-[N'-(2-(5-Methyl-4-imidazolylmethylthio)ethyl)guanidino]ethane
Reaction equation
[NH2:1][CH2:2][CH2:3][NH2:4].S([O-])([O-])(=O)=O.CS[C:12]([NH2:24])=[NH+:13][CH2:14][CH2:15][S:16][CH2:17][C:18]1[N:19]=[CH:20][NH:21][C:22]=1[CH3:23].CS[C:27]([NH2:39])=[NH+:28][CH2:29][CH2:30][S:31][CH2:32][C:33]1[N:34]=[CH:35][NH:36][C:37]=1[CH3:38]>>[CH3:38][C:37]1[NH:36][CH:35]=[N:34][C:33]=1[CH2:32][S:31][CH2:30][CH2:29][N:28]=[C:27]([NH2:39])[NH:1][CH2:2][CH2:3][NH:4][C:12]([NH2:24])=[N:13][CH2:14][CH2:15][S:16][CH2:17][C:18]1[N:19]=[CH:20][NH:21][C:22]=1[CH3:23]Participants
3
Procedure
The reaction of 1,2-diaminoethane (0.60 g) with S-methyl-N-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiouronium sulphate (5.86 g) by the method described in Example 5 afforded the title compound which was isolated as the dipicrate (3.5 g), m.p. 201°-203°.
Sources & evidence
- ORD record
- ord-8b75ba255d7a450e9c5397d9efaa384e
- Source dataset
- uspto-grants-1979_04
- Patent number
- US04151289
Reaction notes
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