HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aminoacetaldehyde → 1-[alpha-(o-Chlorophenyl)-o-tolyl]imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aminoacetaldehyde | HCID 363 | — |
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 2-[(2-Chlorophenyl)methyl]aniline | HCID 13426664 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 1-[alpha-(o-Chlorophenyl)-o-tolyl]imidazole | HCID 21497409 | — |
Reaction Steps
In the manner given in Example 1, α-(0-chlorophenyl)-0-toluidine is reacted first with trimethyl orthoformate; the resulting product is reacted with aminoacetaldehyde, dimethyl acetal, and the resulting product of this reaction is heated with titanium tetrachloride in monoglyme to give 1-[α-(0-chlorophenyl)-0-tolyl]imidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03941802 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-f06bfcfd0f2d436682cbfdbb504b6f16 |
| Source note | uspto-grants-1976_03 |