Ethyl orthoformate → HCID 21497386, compound

HRID 267286Notes

Reaction equation

HRID 267286 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]1[C:10](=[CH:12][CH:13]=[CH:14][CH:15]=1)[NH2:11].[CH:16](OCC)(OCC)OCC.[CH2:26]([C:28]1([CH:33]([NH2:36])[CH2:34][CH3:35])OCCO1)[CH3:27]>[Ti](Cl)(Cl)(Cl)Cl>[CH2:34]([C:33]1[N:36]=[CH:16][N:11]([C:10]2[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=2[CH2:8][C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:28]=1[CH2:26][CH3:27])[CH3:35]

Participants

5

Reactant 3

HCID 31214Ethyl orthoformateHCID 21497428HCID 21497428, compoundHCID 21497429HCID 21497429, compound

Product 1

HCID 21497386HCID 21497386, compound

Reagents, catalysts & solvents 1

HCID 24193Titanium TetrachlorideCatalyst

Procedure

In the manner given in Example 3, α-(0-fluorophenyl)-0-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-ethyl-2-(1-aminopropyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 4,5-diethyl-1-[α-(0-fluorophenyl)-0-tolyl]imidazole.

Sources & evidence

ORD record
ord-3955cb8d93d6444d82acd3c384bf8899
Source dataset
uspto-grants-1976_03
Patent number
US03941802

Reaction notes

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