HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → N-Acetyl-L-phenylalanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-Acetyl-L-phenylalanine | HCID 74839 | — |
| Reactant | Methyl 3-phenyl-DL-alaninate hydrochloride | HCID 3084017 | — |
| Product | N-Acetyl-L-phenylalanine | HCID 74839 | — |
| Product | (R)-Methyl 2-amino-3-phenylpropanoate | HCID 853474 | — |
Reaction Steps
To 310 parts by volume of an aqueous 0.5N sodium hydroxide solution, heated to about 70°, is added, successively, 17.7 parts of N-acetyl-L-phenylalanine and 33.3 parts of DL-phenylalanine methyl ester hydrochloride. A precipitate forms and upon cooling and filtering, the salt of N-acetyl-L-phenylalanine and D-phenylalanine methyl ester is obtained. Recrystallization from hot water affords the pure salt exhibiting an [α]D in 0.5% water of about +32.2°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03941831 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-39fe7e25f49b420b9fc236a8b4116a5c |
| Source note | uspto-grants-1976_03 |