Ammonium Chloride → HCID 431947, compound

HRID 267366Notes

Reaction equation

HRID 267366 reaction equation
Cl[C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=[CH:4][N:3]=1.[Cl-].[NH4+:16]>C(O)C.N>[NH2:16][C:2]1[C:7]([O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][N:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 21557075HCID 21557075, compound

Product 1

HCID 431947HCID 431947, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 702EthanolSolvent

Procedure

4-Chloro-5-phenoxy pyrimidine is dissolved in absolute ethanol saturated with ammonia and added ammonium chloride, and heated in a stainless steel pressure bomb at about 160°C. for approximately 6 hours. The ethanol is removed under vacuum, and the oily residue taken up in ether. Concentration of the ether extract gives 4-amino-5-phenoxy pyrimidine as a yellow solid which is taken up in hot ethyl acetate, treated with activated charcoal, filtered and cooled to provide white crystals.

Workup

  1. customThe ethanol is removed under vacuum
  2. extractionConcentration of the ether extract

Sources & evidence

ORD record
ord-b5ce177bc8034aea8bf7466d4c783b16
Source dataset
uspto-grants-1976_03
Patent number
US03941889

Reaction notes

Loading…