Ethyl alpha-iodo-2'-chloro-4-biphenylylacetate → Ethyl alpha-iodo-3-chloro-4-cyclohexylphenylacetate

HRID 267390Notes

Reaction equation

HRID 267390 reaction equation
BrC(C1C=CC(C2C=CC=CC=2[Cl:20])=CC=1)C(OCC)=O.C(NC(=O)C(C1C=CC(C2C=CC=CC=2Cl)=CC=1)Br)(C)C.[I:42][CH:43]([C:49]1[CH:54]=[CH:53][C:52]([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][C:56]=2Cl)=[CH:51][CH:50]=1)[C:44]([O:46][CH2:47][CH3:48])=[O:45].C(NC(=O)C(C1C=CC(C2C=CC=CC=2Cl)=CC=1)I)(C)C>>[I:42][CH:43]([C:49]1[CH:54]=[CH:53][C:52]([CH:55]2[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]2)=[C:51]([Cl:20])[CH:50]=1)[C:44]([O:46][CH2:47][CH3:48])=[O:45]

Participants

5

Reactant 4

HCID 21556207Ethyl alpha-iodo-2'-chloro-4-biphenylylacetate2×HCID 21556258Ethyl alpha-bromo-2'-chloro-4-biphenylylacetate3×HCID 21556317N-isopropyl alpha-iodo-2'-chloro-4-biphenylylacetamideHCID 21556386N-isopropyl alpha-bromo-2'-chloro-4-biphenylylacetamide

Product 1

HCID 21454139Ethyl alpha-iodo-3-chloro-4-cyclohexylphenylacetate

Procedure

When ethyl α-bromo-2'-chloro-4-biphenylylacetate in the above procedure is replaced by d ethyl α-bromo-2'-chloro-4-biphenylylacetate, l ethyl α-bromo-2'-chloro-4-biphenylylacetate of N-isopropyl α-bromo-2'-chloro-4-biphenylylacetamide, then the products prepared are d ethyl α-iodo-2'-chloro-4-biphenylylacetate, l ethyl α-iodo-2'-chloro-4-biphenylylacetate or N-isopropyl α-iodo-2'-chloro-4-biphenylylacetamide.

Workup

  1. customthe products prepared

Sources & evidence

ORD record
ord-3dd25ac919464d6ba6b0c2ec26a2d319
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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