反应详情

To 17.5 ml. of 2N alcoholic potassium hydroxide solution (0.035 mole) is added 4.84 g. (0.035 mole) of thiobenzoic acid. The solution is cooled to room temperature and to this is added in small portions 10.05 g. (0.035 mole) of α, 2'-dichloro-4-biphenylylacetic acid. The reaction mixture is stirred at room temperature for 25 hours, then the solvent is removed, the residue dissolved in ether, filtered and washed with cold water. The ethereal solution is then dried over magnesium sulfate and evaporated to dryness to obtain α-benzoylthio-2'-chloro-4-biphenylylacetic acid.

1. additionto this is added in small portions 10.05 g
2. customthe solvent is removed
3. dissolutionthe residue dissolved in ether
4. filtrationfiltered
5. washwashed with cold water
6. dry with materialThe ethereal solution is then dried over magnesium sulfate
7. customevaporated to dryness