Potassium Hydroxide → HCID 21556259, compound

HRID 267392Notes

Reaction equation

HRID 267392 reaction equation
[OH-].[K+].[C:3]([OH:11])(=[S:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[CH:13]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])=[CH:19][CH:18]=1)[C:14]([OH:16])=[O:15]>>[C:3]([S:10][CH:13]([C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[Cl:29])=[CH:19][CH:18]=1)[C:14]([OH:16])=[O:15])(=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 21523009HCID 21523009, compoundHCID 178526132HCID 178526132, compound

Product 1

HCID 21556259HCID 21556259, compound

Procedure

To 17.5 ml. of 2N alcoholic potassium hydroxide solution (0.035 mole) is added 4.84 g. (0.035 mole) of thiobenzoic acid. The solution is cooled to room temperature and to this is added in small portions 10.05 g. (0.035 mole) of α, 2'-dichloro-4-biphenylylacetic acid. The reaction mixture is stirred at room temperature for 25 hours, then the solvent is removed, the residue dissolved in ether, filtered and washed with cold water. The ethereal solution is then dried over magnesium sulfate and evaporated to dryness to obtain α-benzoylthio-2'-chloro-4-biphenylylacetic acid.

Workup

  1. additionto this is added in small portions 10.05 g
  2. customthe solvent is removed
  3. dissolutionthe residue dissolved in ether
  4. filtrationfiltered
  5. washwashed with cold water
  6. dry with materialThe ethereal solution is then dried over magnesium sulfate
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-1d1b457bfe8d4073a0db16fa36022c4a
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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