Sodium thiocyanate → HCID 21556363, compound

HRID 267394Notes

Reaction equation

HRID 267394 reaction equation
[S-:1][C:2]#[N:3].[Na+].Cl[CH:6]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:12][CH:11]=1)[C:7]([OH:9])=[O:8]>C(O)C>[S:1]([CH:6]([C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:22])=[CH:12][CH:11]=1)[C:7]([OH:9])=[O:8])[C:2]#[N:3]

Participants

4

Reactant 2

HCID 516871Sodium thiocyanateHCID 21523009HCID 21523009, compound

Product 1

HCID 21556363HCID 21556363, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 300 ml. of anhydrous ethanol and 0.15 moles of sodium thiocyanate is added 35 g. (0.12 moles) of α, 2'-dichloro-4-biphenylylacetic acid and stirred for 15 hours. The reaction mixture is filtered and washed with absolute ethanol. The filtrate is evaporated to dryness, the residue is dissolved in 250 ml. of ether and washed several times with water. The ether is then dried and evaporated to dryness to obtain α-thiocyanato-2'-chloro-4-biphenylylacetic acid.

Workup

  1. filtrationThe reaction mixture is filtered
  2. washwashed with absolute ethanol
  3. customThe filtrate is evaporated to dryness
  4. dissolutionthe residue is dissolved in 250 ml
  5. washof ether and washed several times with water
  6. dry with materialThe ether is then dried
  7. customevaporated to dryness

Sources & evidence

ORD record
ord-f94660ec22754beb9bb62db294d29f99
Source dataset
uspto-grants-1976_03
Patent number
US03941821

Reaction notes

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