Potassium Hydroxide → 4-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

HRID 267408Notes

Reaction equation

HRID 267408 reaction equation
[NH2:1][C:2]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:3]=1[C:4](=NN)[C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[F:12].[OH-].[K+]>C(O)COCCO>[Cl:19][C:16]1[CH:15]=[C:3]([CH2:4][C:5]2[C:6]([F:12])=[CH:7][CH:8]=[CH:9][C:10]=2[F:11])[C:2](=[CH:18][CH:17]=1)[NH2:1]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 867330922-Amino-5-chloro-2',6'-difluorobenzophenone hydrazone

Product 1

HCID 214973734-Chloro-alpha-(2,6-difluorophenyl)-o-toluidine

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

In the manner given in Preparation 11, 2-amino-5-chloro-2',6'-difluorobenzophenone hydrazone is refluxed with potassium hydroxide in diethylene glycol to give 4-chloro-α-(2,6-difluorophenyl)-o-toluidine.

Sources & evidence

ORD record
ord-3b42da7d8fd1430c93dd29ccd553df67
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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