Potassium Hydroxide → 4-Fluoro-alpha-phenyl-o-toluidine

HRID 267412Notes

Reaction equation

HRID 267412 reaction equation
[NH2:1][C:2]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:3]=1[C:4](=NN)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[OH-].[K+]>C(O)COCCO>[F:17][C:14]1[CH:13]=[C:3]([CH2:4][C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:2](=[CH:16][CH:15]=1)[NH2:1]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 867331112-Amino-5-fluorobenzophenone hydrazone

Product 1

HCID 214974014-Fluoro-alpha-phenyl-o-toluidine

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

In the manner given in Preparation 11, 2-amino-5-fluorobenzophenone hydrazone is refluxed with potassium hydroxide in diethylene glycol to give 4-fluoro-α-phenyl-o-toluidine.

Sources & evidence

ORD record
ord-d7f89652ceb84151950307d7afc9991e
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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