Potassium Hydroxide → 4-(Trifluoromethyl)-alpha-phenyl-o-toluidine

HRID 267414Notes

Reaction equation

HRID 267414 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=O.[OH-].[K+]>C(O)COCCO>[F:17][C:16]([F:18])([F:19])[C:13]1[CH:12]=[C:3]([CH2:4][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[CH:15][CH:14]=1)[NH2:1]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 13014169(2-Amino-5-(trifluoromethyl)phenyl)(phenyl)methanone

Product 1

HCID 200619714-(Trifluoromethyl)-alpha-phenyl-o-toluidine

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

In the manner given in Preparation 11, 2-amino-5-(trifluoromethyl)benzophenone is refluxed with potassium hydroxide in diethylene glycol to give 4-(trifluoromethyl)-α-phenyl-o-toluidine.

Sources & evidence

ORD record
ord-553a518c8d1c4dfdad2db1b39df3b847
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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