Formaldehyde → 2',5-Dichloro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone

HRID 267419Notes

Reaction equation

HRID 267419 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:21])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH:20]=[CH:19][N:18]=[CH:17]1.[CH2:22]=[O:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:21])[C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH:20]=[CH:19][N:18]=[C:17]1[CH2:22][OH:23]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 143578782',5-Dichloro-2-(imidazol-1-yl)benzophenone

Product 1

HCID 215558792',5-Dichloro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone

Procedure

In the manner given in Example 1, 3.16 g. of 2',5-dichloro-2-(imidazol-1-yl)benzophenone is heated in a bomb with 37% aqueous formaldehyde solution to give 2',5-dichloro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record
ord-c3ad6852c597425f89b5389305124b5c
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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