Formaldehyde → HCID 21555834, compound

HRID 267421Notes

Reaction equation

HRID 267421 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]2[CH:21]=[CH:20][N:19]=[CH:18]2)=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=[O:8].[CH2:22]=[O:23]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:17]2[CH:21]=[CH:20][N:19]=[C:18]2[CH2:22][OH:23])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=[O:8]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 21497377HCID 21497377, compound

Product 1

HCID 21555834HCID 21555834, compound

Procedure

In the manner given in Example 1, 5-chloro-2'-fluoro-2-(imidazol-1-yl)benzophenone is heated in a bomb with 37% aqueous formaldehyde solution to give 5-chloro-2'-fluoro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record
ord-b331bfd220684fbb88e5506f355a2aaa
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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