Formaldehyde → HCID 21555842, compound

HRID 267423Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[CH:22]=[CH:21][N:20]=[CH:19]2)=[C:6]([CH:17]=1)[C:7]([C:9]1[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])=[O:8].[CH2:23]=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[CH:22]=[CH:21][N:20]=[C:19]2[CH2:23][OH:24])=[C:6]([CH:17]=1)[C:7]([C:9]1[C:10]([F:16])=[CH:11][CH:12]=[CH:13][C:14]=1[F:15])=[O:8]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 21497359HCID 21497359, compound

Product 1

HCID 21555842HCID 21555842, compound

Procedure

In the manner given in Example 1, 5-chloro-2',6'-difluoro-2-(imidazol-1-yl)benzophenone is heated in a bomb to 150° C. with 37% aqueous formaldehyde solution to give 5-chloro-2',6'-difluoro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record: ord-cbd931a790b346eeafd6f1896c8f8ef6
Source dataset: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03941803

Reaction notes

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