Formaldehyde → HCID 21555887, compound

HRID 267425Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:25])[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1[N:19]1[C:23]([CH3:24])=[CH:22][N:21]=[CH:20]1.[CH2:26]=[O:27]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:25])[C:9]1[CH:14]=[C:13]([C:15]([F:16])([F:18])[F:17])[CH:12]=[CH:11][C:10]=1[N:19]1[C:23]([CH3:24])=[CH:22][N:21]=[C:20]1[CH2:26][OH:27]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 21555831HCID 21555831, compound

Product 1

HCID 21555887HCID 21555887, compound

Procedure

In the manner given in Example 1, 2'-chloro-5-(trifluoromethyl)-2-(5-methylimidazol-1-yl)benzophenone is heated in a bomb with 37% aqueous formaldehyde solution to give 2'-chloro-5-(trifluoromethyl)-2-[2-(hydroxymethyl)-5-methylimidazol-1-yl]benzophenone.

Sources & evidence

ORD record: ord-69e1a9095d1848c69252575d06035e79
Source dataset: uspto-grants-1976_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03941803

Reaction notes

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