Formaldehyde → HCID 21555828, compound

HRID 267430Notes

Reaction equation

HRID 267430 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[CH:20]=[CH:19][N:18]=[CH:17]2)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[CH2:21]=[O:22]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[CH:20]=[CH:19][N:18]=[C:17]2[CH2:21][OH:22])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)=[O:8]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 21497380HCID 21497380, compound

Product 1

HCID 21555828HCID 21555828, compound

Procedure

In the manner given in Example 1, 5-fluoro-2-(imidazol-1-yl)benzophenone is heated in a bomb to 150° C. with 37% aqueous formaldehyde solution to give 5-fluoro-2-[2-(hydroxymethyl)imidazol-1-yl]benzophenone.

Sources & evidence

ORD record
ord-8258bb448fc94cc59c59096d16feded8
Source dataset
uspto-grants-1976_03
Patent number
US03941803

Reaction notes

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