Hydrazine → HCID 14357893, compound

Participants

Reaction Steps

5-Chloro-2-[2-(phthalimidomethyl)imidazol-1-yl]benzophenone (0.883 g., 2.00 mmol) is suspended in 12 ml. of absolute ethanol, treated with hydrazine and heated to 72°-74° C. Within 10 minutes all of the solid dissolves. After 2 hours the reaction is stopped and white solid is removed by filtration. The mother liquor is concentrated in vacuo to an oil which is crystallized from ethyl acetate-hexane-mixtures to give 8-chloro-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine of melting point 143°-148° C.

Provenance & Evidence