HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-Chloroethane → 1-Chloro-2-[4-(4-methylphenylsulfonyl)piperazin-1-yl]ethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(Toluene-2-sulfonyl)-piperazine | HCID 54406424 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 1-Chloro-2-[4-(4-methylphenylsulfonyl)piperazin-1-yl]ethane | HCID 4741932 | 80.6% |
Reaction Steps
After refluxing for 72 hours a reaction mixture consisting of 60 g (0.25 mol) of p-toluenesulfonylpiperazine (III), 41 ml (0.5 mol) of 1-bromo-2-chloroethane and 35 ml (0.25 mol) of triethylamine in 1 liter of benzene, the solution was filtered and white needle crystal were obtained from the filtrate. N-β-chloroethyl-N'-p-toluenesulfonylpiperazine 61 g (yield: 79%) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03943135 |
| Source dataset | uspto-grants-1976_03 |
| ORD ID | ord-040e2e44b322400a9687cec7c04160e8 |
| Source note | uspto-grants-1976_03 |