Diethyl oxalacetate → HCID 68136024, compound

HRID 267528Notes

Reaction equation

HRID 267528 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH2:10]([O:12][C:13](=[O:18])/[CH:14]=[C:15](\[NH2:17])/[CH3:16])[CH3:11].[CH2:19]([O:21][C:22](=[O:31])[CH2:23][C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=O)[CH3:20]>C(O)C>[CH2:10]([O:12][C:13]([C:14]1[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=2)[C:23]([C:22]([O:21][CH2:19][CH3:20])=[O:31])=[C:24]([C:26]([O:28][CH2:29][CH3:30])=[O:27])[NH:17][C:15]=1[CH3:16])=[O:18])[CH3:11]

Participants

5

Reactant 3

HCID 66951Diethyl oxalacetateHCID 680093-FluorobenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-

Product 1

HCID 68136024HCID 68136024, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6.2 g of 3-fluorobenzaldehyde, 6.5 g of β-aminocrotonic acid ethyl ester and 9.5 g of oxalacetic acid diethyl ester in 40 ccs of ethanol are heated to the boil overnight, the mixture is evaporated in vacuo and a light yellow oil is obtained.

Workup

  1. customthe mixture is evaporated in vacuo
  2. customa light yellow oil is obtained

Sources & evidence

ORD record
ord-1be3e2ae1c8f4a429c43502758a4f5e8
Source dataset
uspto-grants-1976_03
Patent number
US03943140

Reaction notes

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