Acetate → HCID 131710090, compound

Participants

Reaction Steps

This crude ester (about 600 mg.) was dissolved in acetone (50 ml.) and pH 5 acetate buffer was added. The solution was refluxed for 45 minutes, then concentrated by evaporation under reduced pressure, diluted with water and extracted with chloroform. The organic solution was dried over sodium sulphate and evaporated to an oil which was purified by preparative TLC and recrystallisation of the main band from acetone/petrol to give title compound (176 mg.) as off-white prisms, m.p. 121°-125°, [α]D + 215°.

Provenance & Evidence