4-Methylthiazole → 1-(4-Methyl-1,3-thiazol-2-yl)propan-1-one

HRID 267663Notes

Reaction equation

HRID 267663 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][S:5][CH:6]=1.C([Mg]Br)C.[C:11](Cl)(=[O:14])[CH2:12][CH3:13]>>[CH3:1][C:2]1[N:3]=[C:4]([C:11](=[O:14])[CH2:12][CH3:13])[S:5][CH:6]=1

Participants

4

Reactant 3

HCID 127484-MethylthiazoleHCID 62324Propionyl chlorideHCID 178418443HCID 178418443, compound

Product 1

HCID 205603521-(4-Methyl-1,3-thiazol-2-yl)propan-1-one

Procedure

b. 4-Methyl-2-propionyl-thiazole was prepared according to the method described in Bull. 20, 702 (1953) by reacting 4-methyl-thiazole with ethyl-magnesium bromide and acylating the obtained Grignard intermediate with propionyl chloride. The product has a b.p. of 83°-88°C./9 mm. Hg.

Sources & evidence

ORD record
ord-2c6fffe5f61043989718bdc6ec0f2988
Source dataset
uspto-grants-1976_03
Patent number
US03943260

Reaction notes

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