3-(aminomethyl)-3,4-dihydro-2H-1,5-benzodioxepin-3-ol → HCID 178464615, compound

HRID 267769Notes

Reaction equation

HRID 267769 reaction equation
[IH:1].CS[C:4](=[NH:8])[NH:5][CH2:6][CH3:7].[OH:9][C:10]1([CH2:21][NH2:22])[CH2:16][O:15][C:14]2[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=2[O:12][CH2:11]1>C(O)C>[IH:1].[OH:9][C:10]1([CH2:21][NH:22][C:4]([NH:5][CH2:6][CH3:7])=[NH:8])[CH2:11][O:12][C:13]2[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=2[O:15][CH2:16]1

Participants

4

Reactant 2

HCID 155572973-(aminomethyl)-3,4-dihydro-2H-1,5-benzodioxepin-3-olHCID 178464634HCID 178464634, compound

Product 1

HCID 178464615HCID 178464615, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of S-methyl-N-ethylisothiourea hydriodide (2.46 g., 10 millimoles), 3-hydroxy-3-aminomethyl-3,4-dihydro-2H-1,5-benzodioxepin 1.95 g. (10 millimoles) from Example 1, Step E, and 20 ml. of ethanol is refluxed for four hours. The solution then is evaporated to a small volume and diluted with ether to afford 3-hydroxy-3-(3-ethylguanidinyl)methyl-3,4-dihydro-2H-1,5-benzodioxepin hydriodide.

Workup

  1. customThe solution then is evaporated to a small volume
  2. additiondiluted with ether

Sources & evidence

ORD record
ord-c333bcf39c5c45c3b5b99b3c1d11a5b0
Source dataset
uspto-grants-1976_03
Patent number
US03944560

Reaction notes

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